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Scientists at Oak Ridge National Laboratory have used their expertise in quantum biology, artificial intelligence and bioengineering to improve the accuracy of the CRISPR Cas9 gene editing tool used to modify microbes for renewable fuels and chemicals production. This research draws on the lab’s understanding of the electronic structure of nucleotides, the molecules that form the building blocks of DNA and RNA, to improve the modeling and design of guide RNA for the CRISPR Cas9 tool.