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Scientists at Oak Ridge National Laboratory have used quantum biology and artificial intelligence to advance CRISPR Cas9 technology for microbial genome editing. This breakthrough allows for more precise genetic modifications in microbes, expanding the potential for renewable fuel and chemical production. The improved CRISPR Cas9 tool relies on a single, unique guide RNA that directs the Cas9 enzyme to bind with and cleave the corresponding targeted site in the genome. This research validates the team’s anecdotal observations that existing models for designing the CRISPR Cas9 machinery behave differently when working with microbes.
