Intelligent systems are improving our ordinary life through the means of cyberphysical systems and cyber systems, such as cloud computing systems, which make use of artificial intelligence to improve the system outcome. Cybersecurity is an important factor to consider when developing intelligent systems, as it relates to the properties of the system to maintain its correct working behavior. This Special Issue welcomes contributions on the challenges to provide an intelligent, secure, and reliable systems, including topics such as machine learning, data science, health systems, and more.