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This article explores the potential of blockchain technology and the Internet of Things (IoT) to revolutionize industries such as finance, supply chain management, healthcare, and smart cities. It highlights the common objective of these innovations to enhance efficiency, security, and transparency, and discusses the advanced mathematical and statistical methods that play a prominent role in their development. The Special Issue focuses on recent theoretical and practical studies of blockchain and IoT, shedding light on their independent advancements and collaborative potential.