Pan-cancer Discovery Of Somatic Mutations From Rna Sequencing Data

A new bioinformatics pipeline, IMAPR, has been developed to identify RNA-SMs in a pan-cancer cohort of 8048 cases from The Cancer Genome Atlas (TCGA). This pipeline addresses limitations of existing methods and has identified over 105,000 novel mutations. A web resource, OncoDB, has also been developed to present pan-cancer mutations in 32 major types of cancer.