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This Special Issue explores the potential applications and challenges of machine learning in the field of medicine. It highlights the growing interface between computer science and medicine, and how the integration of these fields can provide innovative solutions to healthcare challenges. It covers topics such as the use of machine learning in disease classification, diagnosis, treatment, and patient monitoring, as well as ethical implications of using machine learning in healthcare. The Special Issue provides an important platform for researchers and practitioners to share their expertise on this rapidly evolving field and encourage interdisciplinary collaboration to shape the future of medicine.