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Quantum computing is an emerging technology that has the potential to perform high intensive computing tasks, such as data search, prime factorization, machine learning, and artificial intelligence. This Special Issue focuses on the recent advances and challenges in developing large-scale, fault-tolerant quantum computers. Original unpublished papers and review articles are invited on topics such as data search, prime factorization, machine learning, artificial intelligence, and more. Submitted manuscripts should not have been published previously and will be peer-reviewed.