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A team led by Dr. David Baker from the University of Washington has developed a new AI-based approach to engineering protein complexes. This top-down method starts with specific dimensions, shapes, and other properties and uses a machine learning algorithm to build protein complexes tailored to specific biological responses. One example is a 20-sided shell that mimics the outer protective layer of viruses and can be used to create an immune response in mice that outperforms current vaccine candidates. This AI-based approach has potential applications in gene therapies, drug delivery, and more.
