In a new study, researchers revealed that disrupted levels of molecular compounds in maternal blood and cord blood are linked to later diagnosis of autism spectrum disorder (ASD). The study, led by researchers at Columbia University Mailman School of Public Health and the Norwegian Institute of Public Health, used chromatography/mass spectrometry-based metabolomics assays to measure levels of chemical compounds and machine learning to assess the predictive value of the compounds as biomarkers for ASD. The researchers found 12 chemical compounds in maternal mid-gestation (MMG) samples of ASD girls, 3 compounds in MMG samples of ASD boys, 8 compounds in cord blood (CB) samples of ASD girls, and 12 compounds in CB samples of ASD boys to be linked to autism. The study also identified an imbalance of lipid chemical clusters in the maternal blood related to autism in girls, not boys.
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