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Open Access Week 2023 was an opportunity to highlight the benefits of open-access publishing. MDPI, the world’s largest open-access publisher, provides free, immediate access to scientific papers, empowering scientists to examine, validate, replicate, and build upon existing results. Core principles of OA publishing include accessibility, transparency, and collaboration, with the aim of breaking down barriers that have traditionally restricted research access. OA also facilitates interdisciplinary research, encourages collaboration and innovation, and holds the potential to democratize knowledge, advance science, and drive positive societal change. Governments, institutions, and funding agencies have recognized the transformative potential of OA and are driving policy changes to support its growth.