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The 20th ASEAN Ministerial Meeting on Science, Technology, & Innovation (AMMSTI-20) discussed the increasing importance of artificial intelligence (AI) in shaping regional and global socio-economic landscapes. Globally, AI is revolutionising efficiency, reducing costs, and enhancing productivity, with an estimated impact on 1.2 billion jobs and $14.6 trillion in wages over the next decade. Hosted by Cambodia, the meeting reaffirmed the commitment to enhance cooperation in STI to effectively realise the ASEAN Community Blueprints and ASEAN Community Vision.