This article introduces the Future 50 in Dallas-Fort Worth, a list of forward-thinking innovators who are shaping their industries and communities. It highlights the work of Mark Cuban and Alex Oshmyansky’s drug company, which is challenging Big Pharma with a radically transparent online pharmacy, and Treyvon Perry’s startup, which is using 3D printing to build sustainable homes. It also mentions the mission of The Mark Cuban Cost Plus Drug Company, which is not so much making money as it is making healthcare more affordable and accessible.