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This article introduces MMV_Im2Im, a new open-source Python package for image-to-image transformation in bioimaging applications. It is designed with a generic image-to-image transformation framework that can be used for a wide range of tasks, such as semantic segmentation, instance segmentation, image restoration, and image generation. The package takes advantage of state-of-the-art machine learning engineering techniques, allowing researchers to focus on their research without worrying about engineering details. Source code, documentation, and tutorials for MMV_Im2Im are provided in a GitHub repository under an MIT license.