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This Special Issue focuses on original research papers and comprehensive reviews of cutting-edge experimental methodologies for investigating machine or deep learning in minimally invasive surgery (including laparoscopic, endoscopic, and robotic surgery). Topics of interest include, but are not limited to, laparoscopic surgery, deep learning, artificial intelligence, medical innovation, machine learning, trauma, and critical care. Manuscripts should be submitted online and accepted papers will be published continuously in the journal and listed together on the special issue website.