In today’s digital era, organizations are facing new challenges and opportunities brought forth by rapid technological advancements and the shift to a hybrid human-computer intelligence-driven ecosystem. To navigate this dynamic landscape effectively, organizations must deploy a combination of novel management approaches that leverage an abundance mindset, exponential thinking, systems thinking, design thinking, lean six sigma, kaizen and more. Additionally, executives must be prepared to manage the deployment of frontier technologies such as generative and cognitive artificial intelligence, semantic web analysis, spatial and neuromorphic computing, digital twin technologies, 3-D printing, quantum computing, satellite internet, brain-computer interfaces, 10G networks and more. Lastly, leaders must prepare their board, C-suite and teams to navigate a complex digital and business transformation journey.