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Volumetric registration of brain MRI is a routine process used in human neuroimaging, with classical registration techniques being widely used. However, learning-based techniques have emerged in the last 7-8 years, offering advantages such as high computational efficiency and potential for higher accuracy. EasyReg is an open-source, learning-based registration tool that combines the features of classical registration tools, the capabilities of modern deep learning methods, and the robustness to changes in MRI modality and resolution. Results show that EasyReg is as accurate as classical methods when registering 1 mm isotropic scans within MRI modality, but much more accurate across modalities and resolutions.
