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Radiogenomics is a field of precision medicine that focuses on the relationship between genomics and imaging phenotypes. It is used to address tumour heterogeneity, predict immune responsiveness and progression, and provide voxel-by-voxel genetic information. Radiogenomics can be used to distinguish benign from malignant entities, stratify patients according to disease risk, and enable more precise imaging and screening. This article outlines the main applications of radiogenomics in diagnosis, treatment planning and evaluations in the field of oncology, and discusses the challenges and scope of these methods.