Estimating Individual Trajectories Of Structural And Cognitive Decline In Mild Cognitive Impairment For Early Prediction Of Progression To Dementia Of The Alzheimer’s Type

In this study, researchers used data from the Alzheimer’s Disease Neuroimaging Database to evaluate whether individual rates of loss of volumes of the Hippocampus and entorhinal cortex (EC) with age in the MCI stage can predict progression to DAT. They found that the loss of Hippocampal volume is significantly more rapid in MCI-Converters than Non-Converters and that the rate of hippocampal volume loss in the MCI stage is a significant predictor of conversion to DAT. Additionally, individual estimates of rates of regional volume loss in both the Hippocampus and EC, and other additional regions, correlate strongly with individual rates of cognitive decline.