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OpenEvidence, a startup valued at $425 million, is tackling one of AI’s big engineering challenges: large language models whose training is stuck in the past. The challenge involves granting the AI access to a real-time firehose of clinical documents, allowing it to answer questions with an open book, as opposed to a closed book. OpenEvidence is led by founder Daniel Nadler, who sold his previous company, Kensho Technologies, to S&P Global for $550 million.