This article discusses the impact of the future of cookie-less pharma advertising, and the need for companies to adjust, evolve, and adapt to deliver real-time personalization without relying on third-party cookies. It examines the ways in which healthcare provider targeting will not be heavily affected and how it is essential to find ways to deliver personalized ads without personal identifying information. Lastly, it looks at the importance of understanding customer preferences and behavior in order to develop effective strategies.