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This article features thirty industry leaders discussing the most effective use of AI in healthcare settings. The Department of Veterans Affairs has created an Artificial Intelligence Institutional Review Board and an AI Oversight Committee to review its usage of AI tools in clinical settings. Tina Esposito, System Vice President and Chief Health Information Officer at Advocate Health, explains that AI is most effective when success is defined in terms of validity of the AI model, efficiency gains, and improved outcomes. Salim Saiyed, MD, Vice President and Chief Medical Officer of Diplomate Clinical Informatics at UPMC, states that two important uses of AI are improving the accuracy of diagnoses and helping clinicians make better decisions.