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This article discusses how the SARS-CoV-2 virus reshapes the subcellular organization and organelles of its target cells in order to boost virus production and delay antiviral responses. Using label-free microscopy, researchers were able to capture and quantify these alterations in real time. The most noticeable change was the formation of syncytia, where infected cells fuse with neighboring cells. Other changes included clustering of nuclei, accumulation of lipid droplets, and redistribution of mitochondria. These findings provide insight into the mechanisms of SARS-CoV-2 infection and could potentially lead to new treatments.