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Eric Jones, PhD, founder and CEO of Enthought, has been providing AI/ML solutions to solve complex scientific problems for over 20 years. ChatGPT is a chatbot application that leverages a generative pretrained transformer (GPT), a deep-learning neural network model. Several technical breakthroughs in the past 20 years enabled the emergence of ChatGPT, such as learning algorithms, generative networks, models of attention, access to large amounts of data, access to scalable computing resources, and reinforcement learning methods. Business opportunities presented by ChatGPT can be categorized into low-hanging fruit, mid-level opportunities, and long-term opportunities.