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This chapter discusses the global regulatory landscape in the three major developing areas of real world evidence, health data, and AI/Machine Learning across the key jurisdictions of the United States, Europe and China. It also examines the concept of eHealth and other digital health technologies, such as the internet of things, AI, big data, and robotics, which are becoming increasingly important in the way people manage their own health and receive care. The digital health market is currently valued at a high rate.