In this study, wild-type MuStem cells were injected intravenously into young GRMD dogs and the effects on clinical status and tissue organization were observed. The results showed that the GRMD dogs had a close clinical score between 82.0 and 92.1% at the start of the transplantation protocol, and at the end of the protocol, the GRMD dogs showed severe clinical impairments, with scores ranging from 23.3 to 72.6%. In contrast, the GRMDT dogs had much more homogeneous scores, ranging from 75.1 to 87.0%. This suggests that intravenous delivery of MuStem cells results in global improvement in clinical status in GRMD dogs.
